Thioredoxin increases neuronal delayed rectifier K+ current
نویسندگان
چکیده
منابع مشابه
Macrophage migration inhibitory factor increases neuronal delayed rectifier K+ current.
Macrophage migration inhibitory factor (MIF) has widespread actions in the immune, endocrine, and nervous systems. Previously, we reported that increases in the intracellular levels of MIF depress the firing of hypothalamus/brain stem neurons in culture, including the chronotropic actions of angiotensin II. The objective of this study was to investigate the effects of MIF on delayed rectifier K...
متن کاملBasal and angiotensin II-inhibited neuronal delayed-rectifier K+ current are regulated by thioredoxin.
In previous studies, we determined that macrophage migration inhibitory factor (MIF), acting intracellularly via its intrinsic thiol-protein oxidoreductase (TPOR) activity, stimulates basal neuronal delayed-rectifier K(+) current (I(Kv)) and inhibits basal and angiotensin (ANG) II-induced increases in neuronal activity. These findings are the basis for our hypothesis that MIF is a negative regu...
متن کاملMacrophage migration inhibitory factor (MIF) increases neuronal delayed rectifier K current
Macrophage migration inhibitory factor (MIF) has widespread actions in the immune, endocrine and nervous systems. Previously, we reported that increases in the intracellular levels of MIF depress the firing of hypothalamus/brainstem neurons in culture, including the chronotropic actions of angiotensin II (Ang II). The objective of this study was to investigate the effects of MIF on delayed rect...
متن کاملAngiotensin II increases neuronal delayed rectifier K(+) current: role of 12-lipoxygenase metabolites of arachidonic acid.
Angiotensin II (Ang II) elicits an Ang II type 2 (AT(2)) receptor-mediated increase in voltage-dependent delayed rectifier K(+) current (I(KV)) in neurons cultured from newborn rat hypothalamus and brain stem. In previous studies, we have determined that this effect of Ang II is mediated via a Gi protein, activation of phospholipase A(2) (PLA(2)), and generation of arachidonic acid (AA). AA is ...
متن کاملExistence of a delayed rectifier K+ current in the membrane of human embryonic stem cel
Introduction: Human embryonic stem cells (hESCs) are pluripotent cells that can proliferate and differentiate to many cell types. Their electrophysiological properties have not yet been chracterzed. In this study, the passive properties (such as resting membrane potential, input resistance and capacitance) and the contribution of delayed rectifier K+ channel currents to the membrane conducta...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2006
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.20.5.lb23-b